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Gastric ulcer: the therapeutic and preventive effect of Chinese herbal medicine

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Gastric ulcer: the therapeutic and preventive effect of Chinese herbal medicine

Date of release:2019-05-05 Author: Click:


Gastric ulcer is a multifactorial disease, prevention is better than cure. The drug used to treat gastric ulcers has several disadvantages as a prevention; Due to the limited effectiveness of these drugs in ulcer prevention, many available anti-ulcer drugs have side effects and gastric ulcer treatment drugs are more expensive. Herbs can provide another form of protection against gastric ulcers because they are safer and cheaper and often have fewer(if any) side effects.
Due to its effectiveness, fewer side effects and relatively low price costs, the need for more effective and cheaper management and prevention of gastric ulcers has promoted the study of Chinese herbs. For a long time, some herbal ingredients and food additives have been known to have gastric protective effects. For example, licorice has been used as a stomach protector.


Lilac is a compound extracted from clove oil and has a protective effect on the formation of indomethin-induced gastric ulcers. This action is mediated by its antioxidant activity, reducing acid-pepsin secretion and increasing mucus production. Similarly, curcumin showed protective effects on gastric ulcers by inhibiting gastric acid secretion, relieving oxidative stress and improving apoptosis. According to reports, many Chinese natural plant chemicals have effective gastric protection against Helicobacter pylori. Hemolytic phospholipid acid is a component of soybean lecithin and has a protective effect on gastric ulcers induced in animal models. It shows that daily intake of foods rich in hemolytic phosphatide acid or Chinese medicine may be conducive to preventing gastric ulcers. In the process of finding biologically active natural products from herbal sources with ulcerative protective activity, humans have tried plant extracts and plant-derived compounds in different experimental models.


Herbal extract
Several studies have been conducted on the gastric protective effects of plant extracts. Although the pathogenesis of gastric ulcer is multiple factors, the secretion of gastric acid is still considered to be the main cause of this disease; Therefore, the main therapeutic target is the use of anti-acid secretion drugs to control this secretion. On the other hand, many plant extracts significantly reduce the ulcer index of experimental animals, but there is no clinical effect due to their lack of anti-secretion activity. These natural herbal extracts with stomach protection include the methanol extract of the bark of Abarema cochliacarpos, a plant mainly grown in Brazil. Baiqin, another widely used global food additive, was also tested for its anti-secretion properties. The main herbal extracts grown and widely used in India were tested for gastric protection, water extracts from the leaves of dendrobium, methanol extracts from the white flower snake grass, methanol extracts from pomegranates, and water extracts from fragrant peach berries, Extracts of camphor leaves and fruit extracts from the fruit of the fruit, skunk bark and camel thorns widely used in Egypt have shown protective effects on gastric ulcers. Hot water extracts of cucumber pollen, mainly used in Sri Lanka, also showed similar effects.


Pure compound
Purified compounds may have the characteristics of compounds designated for gastric protection. Unlike herbal extracts, pure compounds may lack the presence of several combinations that may contradict each other's actions or increase side effects.


Flavonoids
Flavonoids represent a highly diversified class of secondary metabolites that constitute the largest and most important polyphenols in plants. The multiple effects of natural compounds are important for the development of new drugs for multi-factor diseases. This is particularly true for flavonoids, which exhibit several pharmacological properties in gastric protective areas, acting as antisecretes, cell protectors and antioxidants. In addition to their role as gastric protection, flavonoids can also be used as substitutes to inhibit or regulate gastric ulcers associated with Helicobacter pylori. Flavonoids extracted from the leaves of Mouriri pusa, a plant from Pilate, Brazil, are commonly used to treat gastrointestinal disorders and have shown beneficial effects in preventing and reversing gastric ulcers. Quercetin has an anti-secretion mechanism. Therefore, it has anti-histamine characteristics, which can reduce the level of histamine, while preventing histamine from being released from large cells of stomach fertilizer, inhibiting stomach H + / K + proton pump, and reducing gastric acid secretion.
On the other hand, the gastric protective effect of Charerone involves increasing mucosal blood flow, stimulating the synthesis of mucus in the gastric mucosa and increasing prostaglandin levels. However, the most important mechanism responsible for the anti-ulcer activity of flavonoids is their antioxidant properties, found in mountain bamboo, rutin, and quercetin, which involve the removal of free radicals, transitional metal ion chelation, inhibition of oxidase, increase of protein and non-protein antioxidants and reduction of lipid peroxidation. In addition, Chaertong and quercetin(flavonol) have anti-Helicobacter pylori activity. Quercetin has an anti-secretion mechanism. Therefore, it has anti-histamine characteristics, which can reduce the level of histamine, while preventing histamine from being released from large cells of stomach fertilizer, inhibiting stomach H + / K + proton pump, and reducing gastric acid secretion.


Alkaloids
Alkaloids represent a group of low-molecular weight nitrogen-containing secondary metabolites with gastric protective activity. For example, isoquinoline alkaloids separated from beryllium and beryllium; matrine alkaloids, matrine, reduce acid secretion, inhibit gastric power; Piperidine, a piperidine, protects the stomach from ulcers by reducing gastric juice, stomach acidity, and pepsinin-A activity; Phenylalkyl amide alkaloid capsaicin, inhibits acid secretion, stimulates alkali/mucus secretion, and mainly increases gastric mucosal blood flow; The steroid alkaloid rich grass alkaloid A obtained from rich grass; The indole alkaloid bitter wood ketone found in bitter wood can reduce gastric acid/pepsin secretion and protect mucous membranes.


Terpenoids
Terpenoids are a large and diverse class of natural organic chemicals similar to terpenes. Protective terpenoids have been isolated from several plants, including terpenes from Artemisia halodendron, triterpenoids from Fabiyanafuwayan, and glycyrrhizic acid from light fruit licorice to prevent gastric ulcers. Most of the work on gastric protection activities is concentrated in Kelaowan dinerpenoids from the genus Batou. Other antiulcer diterpenoids include cordatin from aphids and Trichophyton from Buttercup A.
Therefore, Chinese herbal extracts are a promising method for treating and preventing gastric ulcers.

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