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Alzheimers disease:

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Alzheimers disease:

Date of release:2019-06-14 Author: Click:

Yeerbasangta is a plant with a long history of medicinal use in California. It contains an active compound that can one day treat people with Alzheimer's disease.
That's the conclusion of scientists at the solk biological Institute in La Hoa, Calif., who tested 400 known extracts of medicinal plants.
Using a new drug to detect screens, they tested the ability of these compounds to prevent brain aging.
The first round of tests produced several extracts that can prevent a cell death from Alzheimer's disease and other age-related diseases.
Further tests show that the California Lotus extract sterubin, or Yerba Santa, is the most resistant to inflammation and other causes of brain cell death.
Californian tribes have long valued Yeerba, which means "Holy herb" in Spanish. It is a drug that treats respiratory diseases, fever, infections, bruises, pain and headaches.
The researchers described their findings in a paper published in the journal Redox biology.
"Alzheimer's," said Pamela Maher, a senior scientist at the Salk Institute and a leading cause of death in the United States. "
"And," she added, "because age is a major risk factor, researchers are looking for ways to combat the effects of aging on the brain. "
She pointed out that they "are for sterubin[ Is a promising step in this direction.
The discovery of Alzheimer's and drugs
Alzheimer's disease is a brain disease that causes irreversible and progressive cell death. This is the most common cause of dementia.
So far, there are no treatments to cure or stop Alzheimer's disease, although some can slow or slow the progression of symptoms for a period of time.
According to a report in the 2018 International Alzheimer's Disease, dementia affects 50 million people worldwide, two thirds of whom have Alzheimer's.
In the United States by 2050, the number of people with Alzheimer's disease in the United States will increase from about 5.7 million to nearly 14 million.
Despite some exceptions, Alzheimer's most often affects older people, making age growth the most important risk factor.
The effects of Alzheimer's on the brain began long before symptoms of dementia, such as memory loss, appeared.
The "main suspects" behind these changes are the formation of amyloid toxic plaques between nerve cells and the accumulation of tau protein toxic tangles in cells.
Much of the research and development behind Alzheimer's treatment tends to focus on these and other features and how to stop them.
However, as the authors explain in their research paper, since age is the most important risk factor for Alzheimer's disease "so far", there must be "a strong theoretical basis based on the biology of aging. Find an alternative drug discovery. "
The researchers suggest that screening tools should be able to detect a variety of age-related pathways that kill brain cells, rather than a single molecular target.
New screening tool
In previous studies, the researchers used a screening method to identify plant-based flavonoids that reduce inflammation and protect nerve cells.
On this basis, they developed a screening tool, including testing or testing, whose function is not only to identify compounds that may protect cells.
The new tool, they argue, could also identify "target pathways" for these compounds, potentially making them new molecular targets for drug developers.
The team first tested the ability of all 400 plant extracts to inhibit oxytocin in rat hippocampal nerve cells. Propulsive labor is a cell death that occurs in Alzheimer's disease.
Pass the extract of this test and then perform further tests. These studies examined the activity of the compound in a number of senescence related nerve cell functions and pathways that are "directly related" to Alzheimer's disease. Some experiments use mouse cells, while others use human cells.
One of the reasons sterubin stands out is that it shows a powerful ability to reduce inflammation in microglia, the brain cells that support nerve cells.
Iron removal
Sterubin also showed the ability to remove iron from cells. The accumulation of iron can lead to damage to a nerve cell that accompanies aging. This damage occurs in neurodegenerative diseases.
Researchers now plan to use animal models to determine the drug properties and safety levels of steroids in animals.
From there, they can test on humans. However, to do this with natural extracts, it must come from plants that grow under controlled conditions and then be purified.
Maher believes that the more likely method in the future is to synthesize this compound.
"Not only have we found that sterubin is much more active than other flavonoids in Santa Claus, but it seems to be as good or even better than other flavonoids we 've studied. " -- Pamela Maher

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